"O'Rourke was born on January 18, 1969 in Chicago, Illinois. He is an alumnus of DePaul University. He has released albums of jazz, noise, glitchy electronica and rock music. O'Rourke has collaborated with Thurston Moore, Lee Ranaldo, Derek Bailey, Mats Gustafsson, Mayo Thompson, Brigitte Fontaine, Loren Mazzacane Connors, Merzbow, Nurse with Wound, Phill Niblock, Fennesz, Organum, Phew, Henry Kaiser, Flying Saucer Attack, and in 2006 mixed Joanna Newsom's album Ys. In 2009, he also mixed several tracks on Newsom's follow up Have One On Me.

He has produced albums by artists such as Sonic Youth, Wilco, Stereolab, Superchunk, Kahimi Karie, Quruli, John Fahey, Smog, Faust, Tony Conrad, The Red Krayola, Bobby Conn, Beth Orton, Joanna Newsom and U.S. Maple. He mixed Wilco's Yankee Hotel Foxtrot album and produced their 2004 album, A Ghost Is Born, for which he won a Grammy Award for "Best Alternative Album". During the recording of Yankee Hotel Foxtrot, O'Rourke collaborated with Wilco member Jeff Tweedy and pre-Wilco Glenn Kotche under the name Loose Fur. Their self-titled debut was released in 2003 with a follow-up in 2006 entitled Born Again in the USA. He also mixed the unfinished recordings that made up a planned third album by the late American singer-songwriter Judee Sill, recorded in 1974 and mixed by O'Rourke for a 2005 release.

O'Rourke was once a member of Illusion of Safety, Gastr Del Sol (with David Grubbs) and Sonic Youth. Beginning in 1999 he played bass guitar, guitar and synthesizer with Sonic Youth, in addition to recording and mixing duties with the group. He withdrew as a full member in late 2005, but continued to play with them in some of their side projects. In the early 1993, O'Rourke formed an avant-rock group with Darin Gray and Dylan Posa called Brise-Glace. The band released one studio album, When in Vanitas..., in 1994. They also released a 7" in the same year titled In Sisters All and Felony/Angels on Installment Plan.

O'Rourke has also released many albums under his own name on a variety of labels exploring a range of electronic and avant-garde styles. His most well-known works may be his series of releases on Drag City, which focus on more traditional songcraft: Bad Timing (1997), Eureka (1999), Insignificance (2001), The Visitor (2009) and Simple Songs (2015). The titles of the first four albums all refer to films by the British director Nicolas Roeg; the first three by direct reference to film titles, the fourth being titled after a fictional album within Roeg's film The Man Who Fell To Earth. With music director Takehisa Kosugi, he played for the Merce Cunningham dance company for four years. O'Rourke received a 2001 Foundation for Contemporary Arts Grants to Artists Award."

Composer Brunhild Meyer, aka Brunhild Meyer-Ferrari, the wife and long-time collaborator of French composer Luc Ferrari. She currently resides in Montreuil (Seine-Saint-Denis, France).